Abstract
A series of highly potent HIV protease inhibitors have been designed and synthesized. These compounds are active against various clinical viral isolates as well as wild-type virus. The synthesis and biological activity of these HIV protease inhibitors are discussed.
MeSH terms
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Amines
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Anti-HIV Agents / chemical synthesis*
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Anti-HIV Agents / pharmacology
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Cell Line
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Drug Design
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HIV Protease Inhibitors / chemical synthesis*
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HIV Protease Inhibitors / pharmacology
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Heterocyclic Compounds
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Humans
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Inhibitory Concentration 50
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Mutation
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Oligopeptides / chemical synthesis
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Oligopeptides / pharmacology
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Structure-Activity Relationship
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Virus Replication / drug effects
Substances
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Amines
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Anti-HIV Agents
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HIV Protease Inhibitors
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Heterocyclic Compounds
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Oligopeptides